Mark R Hutchinson Selected Research

Opioid-Related Disorders (Opiate Addiction)

1/2014	Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction.
8/2011	Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: comparison of different mouse strains.
1/2010	Evidence that opioids may have toll-like receptor 4 and MD-2 effects.
11/2009	Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence.
11/2007	Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward.
11/2007	"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids.
7/2007	Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes.
2/2007	Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids.

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Mark R Hutchinson Research Topics

Disease

41	Pain (Aches) 01/2023 - 08/2004
21	Hyperalgesia 01/2022 - 11/2008
20	Neuralgia (Stump Neuralgia) 01/2020 - 02/2007
19	Chronic Pain 01/2023 - 03/2009
11	Inflammation (Inflammations) 05/2024 - 11/2013
8	Opioid-Related Disorders (Opiate Addiction) 01/2014 - 02/2007
7	Neuroinflammatory Diseases 05/2021 - 04/2012
5	Infections 07/2023 - 09/2009
4	Headache (Headaches) 01/2021 - 01/2013
4	Premature Birth (Birth, Premature) 04/2020 - 11/2016
4	Substance-Related Disorders (Drug Abuse) 01/2018 - 01/2014
4	Respiratory Insufficiency (Respiratory Failure) 10/2014 - 11/2008
3	Endometriosis 01/2021 - 01/2017
3	Wounds and Injuries (Trauma) 03/2019 - 01/2015
3	Weight Loss (Weight Reduction) 05/2016 - 02/2009
2	Atherosclerosis 05/2024 - 10/2019
2	Peripheral Nerve Injuries 01/2022 - 11/2008
2	Cognitive Dysfunction 01/2021 - 01/2017
2	Dysmenorrhea (Menstrual Pain) 01/2021 - 01/2020
2	Pelvic Pain 01/2021 - 01/2021
2	Multiple Sclerosis 10/2020 - 04/2020
2	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2020 - 03/2019
2	Perinatal Death 01/2020 - 11/2016
2	Fetal Death 01/2020 - 11/2016
2	Hyperthermia 09/2019 - 01/2019
2	Diarrhea 05/2016 - 01/2016
2	Secondary Headache Disorders 10/2015 - 01/2013
2	Rupture 09/2015 - 12/2014
2	Mastitis 07/2014 - 05/2014
1	Necrosis 07/2023
1	Contracture 07/2023
1	Athletic Injuries (Sports Injuries) 07/2021
1	Chemotherapy-Related Cognitive Impairment 01/2021
1	Malaria 01/2021
1	Arthritis (Polyarthritis) 01/2021
1	Osteitis 01/2021
1	Central Nervous System Diseases (CNS Diseases) 01/2021
1	Nervous System Diseases (Neurological Disorders) 04/2020
1	Parkinson Disease (Parkinson's Disease) 04/2020
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 04/2020

Drug/Important Bio-Agent (IBA)

31	Opioid Analgesics (Opioids)IBA 01/2023 - 08/2004
17	Toll-Like Receptor 4IBA 01/2022 - 07/2008
15	CytokinesIBA 01/2021 - 02/2007
15	Morphine (MS Contin)FDA LinkGeneric 10/2020 - 02/2007
8	Analgesics (Analgesic Drugs)IBA 10/2020 - 12/2005
8	Naloxone (Narcan)FDA LinkGeneric 04/2020 - 07/2008
8	Biomarkers (Surrogate Marker)IBA 01/2020 - 08/2004
6	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2020 - 11/2007
5	LipopolysaccharidesIBA 01/2021 - 07/2008
5	Pain-FreeIBA 01/2020 - 01/2012
4	Naltrexone (ReVia)FDA LinkGeneric 04/2020 - 07/2008
4	Narcotic Antagonists (Opioid Antagonists)IBA 04/2020 - 07/2008
4	Proteins (Proteins, Gene)FDA Link 11/2019 - 11/2008
4	Minocycline (Cyclops)FDA LinkGeneric 09/2019 - 11/2008
4	ibudilastIBA 01/2017 - 07/2007
3	ChemokinesIBA 01/2021 - 11/2008
3	salicylhydroxamic acid (SHAM)IBA 03/2019 - 11/2009
3	Dopamine (Intropin)FDA LinkGeneric 01/2019 - 11/2007
3	EndotoxinsIBA 10/2014 - 04/2012
3	Opioid Receptors (Opioid Receptor)IBA 04/2012 - 11/2009
2	LipidsIBA 05/2024 - 04/2020
2	AndrogensIBA 01/2021 - 01/2021
2	Estrogens (Estrogen)FDA Link 01/2021 - 01/2017
2	Platelet Activating FactorIBA 04/2020 - 01/2020
2	Adenosine (Adenocard)FDA LinkGeneric 01/2020 - 11/2009
2	Tetracycline (Achromycin)FDA LinkGeneric 09/2019 - 01/2012
2	Messenger RNA (mRNA)IBA 03/2019 - 11/2008
2	Glial Fibrillary Acidic ProteinIBA 01/2019 - 05/2016
2	Neurotransmitter Agents (Neurotransmitter)IBA 10/2018 - 12/2016
2	Interleukin-1 (Interleukin 1)IBA 08/2017 - 09/2009
2	Irinotecan (Camptosar)FDA LinkGeneric 05/2016 - 01/2016
2	morphine-3-glucuronideIBA 02/2015 - 05/2013
2	ethyl glucuronideIBA 02/2015 - 05/2013
2	GlucuronidesIBA 02/2015 - 05/2013
2	Ethanol (Ethyl Alcohol)IBA 02/2015 - 05/2013
2	Milk Proteins (Milk Protein)IBA 07/2014 - 05/2014
2	Capsaicin (Zostrix)FDA Link 05/2013 - 01/2012
2	Toll-Like Receptor AgonistsIBA 01/2013 - 01/2012
1	CarbonIBA 05/2024
1	Lipoproteins (Lipoprotein)IBA 05/2024
1	CholesterolIBA 05/2024
1	NexusIBA 01/2022
1	Nicotine FDA Link 05/2021
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 05/2021
1	CotinineIBA 05/2021
1	Monoclonal AntibodiesIBA 01/2021
1	artemisinin (artemisinine)IBA 01/2021
1	CollagenIBA 01/2021
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 10/2020
1	Fingolimod Hydrochloride (FTY720)FDA Link 10/2020
1	Vitamin D FDA LinkGeneric 04/2020

Therapy/Procedure

13	Therapeutics 05/2024 - 02/2007
8	Analgesia 12/2016 - 12/2005
4	Drug Therapy (Chemotherapy) 01/2021 - 01/2016
3	Pain Management 01/2023 - 01/2022
2	Fasciotomy 07/2023 - 01/2015
2	Spinal Injections 05/2013 - 11/2009
1	Surgical Amputation (Amputations) 07/2023
1	Castration 01/2022
1	Postoperative Care 07/2021